the comparison of efficacy of adcortyl ointment and topical tacrolimus in treatment of erosive oral lichen planus
نویسندگان
چکیده
background and aims. oral lichen planus (olp) is a common chronic mucocutaneous disease. patients with atrophic and erosive lichen planus often have symptoms of soreness and need proper treatment. the main therapy of olp has been the administration of topical or systemic corticosteroids. potent topical corticosteroids have been increasingly prescribed in the treatment of erosive lichen planus. the purpose of this study was to compare the efficacy of adcortyl ointment (triamcinolone in orabase) with topical tacrolimus for the treatment of erosive oral lichen planus. materials and methods. sixty patients with histopathologically confirmed oral lichen planus were enrolled in the study. the severity of lesions was scored from 0 to 5 according to the criteria described in a previous study. patients were randomly given adcortyl (group a) and topical tacrolimus ointment (group b) and asked to apply the medication on dried lesions 4 times a day. the lesions were evaluated after 4 weeks of treatment. visual analogue scale was used to assess the severity of pain before and after treatment. the severity scores were analyzed using the kruskal-wallis k-sample test. results. the average score of lesions improved from 3.4 to 1.5 in patients who received adcortyl ointment and from 3.2 to 1.2 in patients who received topical tacrolimus ointment. the differences between the improvements in scores were not statistically significant in the two groups. the average pain severity in a and b groups was 8.2 and 7.8 at the beginning of treatment, and 3.5 and 3.2 at the end of treatment, respectively. there was a statistically significant reduction in pain severity in both groups. conclusion. topical tacrolimus is a safe and effective alternative therapy in the treatment of oral lichen planus.
منابع مشابه
The Comparison of Efficacy of Adcortyl Ointment and Topical Tacrolimus in Treatment of Erosive Oral Lichen Planus
BACKGROUND AND AIMS Oral lichen planus (OLP) is a common chronic mucocutaneous disease. Patients with atrophic and erosive lichen planus often have symptoms of soreness and need proper treatment. The main therapy of OLP has been the administration of topical or systemic corticosteroids. Potent topical corticosteroids have been increasingly prescribed in the treatment of erosive lichen planus. T...
متن کاملA comparison of treatment of oral lichen planus with topical tacrolimus and triamcinolone acetonide ointment.
Treatment of symptomatic oral lichen planus remains a challenging problem. This study compared the efficacy of topical tacrolimus ointment with triamcinolone acetonide ointment in patients with oral lichen planus. Twenty patients (group I) were treated with topical tacrolimus 0.1% ointment 4 times daily, and 20 (group II) were treated with triamcinolone acetonide 0.1% ointment 4 times daily. Th...
متن کاملSuccessful treatment of erosive lichen planus with topical tacrolimus.
A 69-year-old woman with a history of colon carcinoma, cirrhosis of the liver secondary to hepatitis C, and erosive oral lichen planus presented to the dermatology clinic for therapeutic options regarding a growing ulceration on her lower lip. In the past year, the ulceration had enlarged and she had begun to develop new, painful, shallow ulcerations in the oral mucosa. In addition, she complai...
متن کاملTreatment of Oral Lichen Planus with Topical Tacrolimus and Triamcinolone Acetonide Ointment — a Comparative Study
The aim of the study was to compare the efficacy and safety of topical Tacrolimus ointment with that of Triamcinolone Acetonide ointment on patients suffering from oral lichen planus. A total of sixty patients (53 females and 07 males, means age 48 years; 30 patients per groups) were treated with Tacrolimus, a calcineurin inhibitor immunosuppresor drug and Triamcinolone acetonide for three mont...
متن کاملComparative effect of tacrolimus 0.1% ointment and clobetasol 0.05% ointment in patients with oral lichen planus.
BACKGROUND Oral lichen planus (OLP) is considered to be an autoimmune disease of unknown aetiology that affects the mucosae, especially the oral cavity. OBJECTIVE We compared tacrolimus 0.1% ointment and clobetasol 0.05% ointment for the treatment of OLP. PATIENTS AND METHODS A total of 32 patients (20 females and 12 males; all white, Italian origin, mean age of 43.6+/-18.4 years; 16 patien...
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عنوان ژورنال:
journal of dental research, dental clinics, dental prospectsجلد ۱، شماره ۳، صفحات ۹۹-۱۰۲
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